ChloroquineV1, Main, Exploration, bibRecord, 000E60

Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria

Identifieur interne : 000E60 ( Main/Exploration ); précédent : 000E59; suivant : 000E61

Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria

Auteurs : Allison Ledoux [Belgique] ; Hinerava Maraetefau [Belgique] ; Olivia Jansen [Belgique] ; Delphine Etienne [Belgique] ; Joëlle Quetin-Leclercq [Belgique] ; Patricia Clerc [Réunion] ; Jacqueline Smadja [Réunion] ; Michel Frédérich [Belgique]

Source :

Planta Medica [ 0032-0943 ] ; 2015.

RBID : Hal:hal-01397518

English descriptors

mix :
- Rutaceae, Réunion Island, Zanthoxylum heterophyllum, antiplasmodial activitiy, malaria, sanshool.

Abstract

! The aim of this study was to evaluate the antiplasmodial properties of Zanthoxylum heterophyllum, an endemic plant from the Mascarene Islands. In vitro antiplasmodial activity of ethyl acetate and dichloromethane crude extracts obtained from leaf samples collected on Reunion Island was evaluated on the Plasmodi-um falciparum 3D7 chloroquine-sensitive strain using a colori-metric method. The major active compound was identified by chromatographic and spectroscopic methods. The best antiplas-modial activity was obtained for the ethyl acetate extract (15 µg/ mL < IC 50 < 50 µg/mL). The major compound was identified as a sanshool derivative, an alkylamide compound that has moderate antimalarial activity (IC 50 = 11.3 µg/mL). This is the first report of the presence of a sanshool derivative in Z. heterophyllum. The moderate antiplasmodial activity of hydroxy-γ-isosanshool was demonstrated for the first time.

Url:

https://hal.univ-reunion.fr/hal-01397518

DOI: 10.1055/s-0035-1545821

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000185
to stream Hal, to step Curation: 000185
to stream Hal, to step Checkpoint: 000107
to stream Main, to step Merge: 000E61
to stream Main, to step Curation: 000E60

Le document en format XML

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<author><name sortKey="Frederich, Michel" sort="Frederich, Michel" uniqKey="Frederich M" first="Michel" last="Frédérich">Michel Frédérich</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-472322" status="INCOMING">          <orgName>Laboratoire de pharmacognosie</orgName>
          <desc>            <address>              <country key="BE"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-93075" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-93075" type="direct"><org type="institution" xml:id="struct-93075" status="VALID">          <orgName>Université de Liège</orgName>
          <desc>            <address>              <addrLine>Place du 20-Août, 7 4000 Liège</addrLine>
              <country key="BE"></country>
            </address>
            <ref type="url">http://www.ulg.ac.be/cms/c_5000/accueil</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Belgique</country>
<placeName><settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Liège</region>
</placeName>
<orgName type="university">Université de Liège</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1055/s-0035-1545821</idno>
<series><title level="j">Planta Medica</title>
<idno type="ISSN">0032-0943</idno>
<imprint><date type="datePub">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Rutaceae</term>
<term>Réunion Island</term>
<term>Zanthoxylum heterophyllum</term>
<term>antiplasmodial activitiy</term>
<term>malaria</term>
<term>sanshool</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>! The aim of this study was to evaluate the antiplasmodial properties of Zanthoxylum heterophyllum, an endemic plant from the Mascarene Islands. In vitro antiplasmodial activity of ethyl acetate and dichloromethane crude extracts obtained from leaf samples collected on Reunion Island was evaluated on the Plasmodi-um falciparum 3D7 chloroquine-sensitive strain using a colori-metric method. The major active compound was identified by chromatographic and spectroscopic methods. The best antiplas-modial activity was obtained for the ethyl acetate extract (15 µg/ mL < IC 50 < 50 µg/mL). The major compound was identified as a sanshool derivative, an alkylamide compound that has moderate antimalarial activity (IC 50 = 11.3 µg/mL). This is the first report of the presence of a sanshool derivative in Z. heterophyllum. The moderate antiplasmodial activity of hydroxy-γ-isosanshool was demonstrated for the first time.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>Réunion</li>
</country>
<region><li>Province de Liège</li>
<li>Province du Brabant wallon</li>
<li>Région wallonne</li>
</region>
<settlement><li>Liège</li>
<li>Louvain-la-Neuve</li>
</settlement>
<orgName><li>Université catholique de Louvain</li>
<li>Université de Liège</li>
</orgName>
</list>
<tree><country name="Belgique"><region name="Région wallonne"><name sortKey="Ledoux, Allison" sort="Ledoux, Allison" uniqKey="Ledoux A" first="Allison" last="Ledoux">Allison Ledoux</name>
</region>
<name sortKey="Etienne, Delphine" sort="Etienne, Delphine" uniqKey="Etienne D" first="Delphine" last="Etienne">Delphine Etienne</name>
<name sortKey="Frederich, Michel" sort="Frederich, Michel" uniqKey="Frederich M" first="Michel" last="Frédérich">Michel Frédérich</name>
<name sortKey="Jansen, Olivia" sort="Jansen, Olivia" uniqKey="Jansen O" first="Olivia" last="Jansen">Olivia Jansen</name>
<name sortKey="Maraetefau, Hinerava" sort="Maraetefau, Hinerava" uniqKey="Maraetefau H" first="Hinerava" last="Maraetefau">Hinerava Maraetefau</name>
<name sortKey="Quetin Leclercq, Joelle" sort="Quetin Leclercq, Joelle" uniqKey="Quetin Leclercq J" first="Joëlle" last="Quetin-Leclercq">Joëlle Quetin-Leclercq</name>
</country>
<country name="Réunion"><noRegion><name sortKey="Clerc, Patricia" sort="Clerc, Patricia" uniqKey="Clerc P" first="Patricia" last="Clerc">Patricia Clerc</name>
</noRegion>
<name sortKey="Smadja, Jacqueline" sort="Smadja, Jacqueline" uniqKey="Smadja J" first="Jacqueline" last="Smadja">Jacqueline Smadja</name>
</country>
</tree>
</affiliations>
</record>

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Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria

Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria

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